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ea0037oc10.3 | Nuclear receptors and signalling | ECE2015

The thyroid hormones antagonize TGFβ responses suppressing fibrosis

Alonso-Merino Elvira , Orozco Rosa M Martin , Llorente Lidia Ruiz , Martinez-Iglesias Olaia , Velasco-Martin Juan P , Fanjul-Rodriguez Luisa F , Regadera Javier , Aranda Ana

Fibrosis represents a major health concern and presently has no successful treatment. Chronic liver fibrosis leads to portal hypertension, cirrhosis, hepatocellular carcinoma and liver failure. Transforming growth factor β (TGFβ), the main profibrogenic factor, mediates its actions mainly through activation of Smad transcription factors. We have previously observed a cross-talk between the thyroid hormone receptors (TRs) and the TGFβ pathway by which the thyroid...

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ea0035p738 | Nuclear receptors and signal transduction | ECE2014

Thyroid receptors antagonizes TGFβ actions in vivo and in culture cells

Merino Elvira Alonso , Martin Orozco Rosa M , Llorente Lidia Ruiz , Fanjul Rodriguez Luisa Fernanda , Martinez-Iglesias Olaia , Velasco-Martin Juan Pedro , Regadera Javier , Aranda Ana

Transforming growth factor beta (TGFβ), which plays a key role in cancer and fibrotic disorders, mediates its actions mainly through activation of Smad transcription factors, which bind to Smad Binding Elements (SBEs) in target genes. We have previously observed that the thyroid hormone T3 blocks transactivation of SBE-containing reporter plasmids by TGFβ, and represses transcription of endogenous TGFβ target genes. We have now analysed the thyroid ho...

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Endocrine Abstracts

The thyroid hormones antagonize TGFβ responses suppressing fibrosis

Thyroid receptors antagonizes TGFβ actions in vivo and in culture cells

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